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London: Double-mutant variant of severe acute respiratory syndrome SARS-CoV-2 — B.1.617 — that has emerged in India, entered certain types of lung and intestine cells with slightly increased efficiency compared with the original wild-type strain, say researchers.

The researchers, including Markus Hoffmann from German Primate Center, also reported that the entry of B.1.617 into the lung and intestinal cells was blocked following treatment with soluble angiotensin-converting enzyme 2 (ACE2) or the serine protease inhibitor Camostat.

However, this host cell entry was not blocked by the monoclonal antibody Bamlanivimab, which has received emergency use authorization (EUA) as a COVID-19 treatment.

Finally, B.1.617 also partially evaded neutralisation by the antibodies induced through natural infection or immunisation with the Pfizer-BioNTech BNT162b2 vaccine, a study that appeared in the preprint repository medRxiv, suggested.

The researcher said that antibody evasion by B.1.617 may contribute to the rapid spread of this variant.

The sharp rise in COVID-19 cases and deaths in India over recent weeks is thought to be caused by the novel variant B.1.617, which harbours eight mutations in the spike protein.

These include the RBD mutations L452R and E484Q, which are known to modulate antibody-mediated neutralisation.

However, the researchers said it is not currently known whether B.1.617 resists this antibody-mediated neutralization.

To test whether B.1.617 is more adept at entering cells, the researchers infected eight cell lines with pseudotyped virus particles expressing spike protein from the original wild-type virus, the B.1.617 variant, or the B.1.351 variant.

Of the eight cell lines tested, the spikes of B.1.617 and B.1351 mediated entry into Calu-3 lung cells and Caco-2 colon cells with slightly increased efficiency, compared with the original strain.

Collectively, the study reveals that antibody evasion by B.1.617 may contribute to the rapid spread of this variant, the team noted.

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} //lastoff = last.offset(); //console.log("**" + lastoff + "**"); });*/ var maindiv = false; var dis = 0; var fbcontainer=""; var fbid = ''; var fb_script=document.createElement('script'); fb_script.text= "(function(d, s, id) {var js, fjs = d.getElementsByTagName(s)[0];if (d.getElementById(id)) return;js = d.createElement(s); js.id = id;js.src="https://connect.facebook.net/en_GB/sdk.js#xfbml=1&version=v2.9";fjs.parentNode.insertBefore(js, fjs);}(document, 'script', 'facebook-jssdk'));"; var fmain = $(".sr2360782"); //alert(x+ "-" + url); var fdiv = '

'; //console.log(fdiv); //$(fb_script).appendTo(fmain); $(fdiv).appendTo(fmain); function fillElementWithAd($el, slotCode, size, targeting){ if (typeof targeting === 'undefined') { targeting = {}; } else if ( Object.prototype.toString.call( targeting ) !== '[object Object]' ) { targeting = {}; } var elId = $el.attr('id'); //console.log("elId:" + elId); googletag.cmd.push(function(){ var slot = googletag.defineSlot(slotCode, size, elId); for (var t in targeting){ slot.setTargeting(t, targeting[t]); } slot.addService(googletag.pubads()); googletag.display(elId); //googletag.pubads().refresh([slot]); }); } $(document).delegate("button[id^='mf']", "click", function(){ fbcontainer=""; fbid = '#' + $(this).attr('id'); var sr = fbid.replace("#mf", ".sr"); $(fbid).parent().children(sr).toggle(); fbcontainer = $(fbid).parent().children(sr).children(".fb-comments").attr("id"); });

function onPlayerStateChange(event){ var ing, fid; //console.log(event + "---player"); $('iframe[id*="video-"]').each(function(){ _v = $(this).attr('id'); //console.log("_v: " + _v); if(_v != event){ //console.log("condition match"); ing = new YT.get(_v); if(ing.getPlayerState()=='1'){ ing.pauseVideo(); } } }); $('div[id*="video-"]').each(function(){ _v = $(this).attr('id'); //console.log("_v: " + _v + " event: " + event); if(_v != event){ //jwplayer(_v).play(false); } }); } function onYouTubePlay(vid, code, playDiv,vx, pvid){ if (typeof(YT) == 'undefined' || typeof(YT.Player) == 'undefined') { var tag = document.createElement('script'); tag.src = "https://www.youtube.com/iframe_api"; var firstScriptTag = document.getElementsByTagName('script')[0]; firstScriptTag.parentNode.insertBefore(tag, firstScriptTag); window.onYouTubePlayerAPIReady = function() { onYouTubePlayer(vid, code, playDiv,vx, pvid); }; }else{onYouTubePlayer(vid, code, playDiv,vx, pvid);} } function onYouTubePlayer(vid, code, playDiv,vx, pvid){ //console.log(playDiv + "Get Youtue " + vid); //$("#"+vid).find(".playvideo-"+ vx).hide(); var player = new YT.Player(playDiv , { height: '450', width: '100%', videoId:code, playerVars: { 'autoplay': 1, 'showinfo': 1, 'controls': 1 }, events: { 'onStateChange': function(event){ onPlayerStateChange(event.target.a.id); } } }); $("#video-"+vid).show(); } function kalturaPlayerAPIReady(code, playDiv,pvid){ var dt=new Date; var nt=dt.getTime(); var vtitle = ""; pre_roll = "https://pubads.g.doubleclick.net/gampad/ads?sz=640x480&iu=/11440465/Zeenews_English_Video/Zeenews_English_Preroll&tfcd=0&npa=0&sz=640x480&gdfp_req=1&output=vast&unviewed_position_start=1&env=vp&impl=s&description_url="+vtitle+"&correlator="+nt;

var sources ={}; var config = { targetId: playDiv, provider: { partnerId: 2504201 }, playback: { pictureInPicture : true, autoplay: true }, advertising: { adBreaks: [{ position: 0, ads: [{ url: [pre_roll] }] }] }, plugins: { ima: { adsResponse: "" } } } var kalturaPlayer = KalturaPlayer.setup(config); if(kalturaPlayer){ kalturaPlayer.reset(); } var videoUrl = code; var mediaid = '"zn' + pvid + '"'; sources = { hls: [{ id: mediaid, url: videoUrl, mimetype: "application/x-mpegURL" }] } kalturaplayerSetup(kalturaPlayer, sources); if (typeof kalturaPlayer !== 'undefined') { doRegisterEvents(kalturaPlayer); } } function kalturaplayerSetup(kalturaPlayer, playbackType){ kalturaPlayer.setMedia({ plugins: {}, sources: playbackType }); }

function doRegisterEvents(kalturaPlayer) { /* player event*/ kalturaPlayer.addEventListener(kalturaPlayer.Event.Core.PLAY, playEvent); kalturaPlayer.addEventListener(kalturaPlayer.Event.Core.PAUSE, pauseEvent); kalturaPlayer.addEventListener(kalturaPlayer.Event.Core.PLAYBACK_ENDED, playbackEndedEvent);

/* ad event */ kalturaPlayer.addEventListener(kalturaPlayer.Event.AD_STARTED, adStartedEvent); kalturaPlayer.addEventListener(kalturaPlayer.Event.AD_COMPLETED, adCompletedEvent); kalturaPlayer.addEventListener(kalturaPlayer.Event.AD_SKIPPED, adSkippedEvent); kalturaPlayer.addEventListener(kalturaPlayer.Event.AD_CLICKED,adClicked); } var vlabel = "https://zeenews.india.com"+$(this).attr("video-path"); var isVideoPlayed = false; var isAdSkippedCompleted = false;

function adStartedEvent(event) { var videotype = "zee english video"; gtag('event', 'Adstarted', { 'event_category': videotype, 'event_label': vlabel}); gtag('event', 'Play', { 'event_category': videotype, 'event_label': vlabel}); isVideoPlayed = true; isAdSkippedCompleted = true; }

function adCompletedEvent(event) { var videotype = "zee english video"; gtag('event', 'Adcompleted', { 'event_category': videotype, 'event_label': vlabel}); isAdSkippedCompleted = true; }

function adSkippedEvent(event) { var videotype = "zee english video"; gtag('event', 'Adskipped', { 'event_category': videotype, 'event_label': vlabel}); isAdSkippedCompleted = true; }

function adClicked(event) { var videotype = "zee english video"; gtag('event', 'Adclicked', { 'event_category': videotype, 'event_label': vlabel}); }

function playbackEndedEvent(event){ var videotype = "zee english video"; gtag('event', 'Complete', { 'event_category': videotype, 'event_label': vlabel}); }

function playEvent(event) { var videotype = "zee english video";

if((isVideoPlayed) && (isAdSkippedCompleted)){ isAdSkippedCompleted = false; }else if((isVideoPlayed)){ gtag('event', 'resume', { 'event_category': videotype, 'event_label': vlabel}); }else{ gtag('event', 'Play', { 'event_category': videotype, 'event_label': vlabel}); isVideoPlayed = true; } }

function pauseEvent(event) { var videotype = "zee english video"; gtag('event', 'Pause', { 'event_category': videotype, 'event_label': vlabel}); }

function AdloadEvent(event) { var videotype = "zee english video"; gtag("event", "kaltura_adloaded", { "event_category": videotype, "event_label": vlabel}); }

function AdProgressEvent(event) { var videotype = "zee english video"; gtag("event", "kaltura_adprogress", { "event_category": videotype, "event_label": vlabel}); }

function adPausedEvent(event) { var videotype = "zee english video"; gtag("event", "kaltura_adpaused", { "event_category": videotype, "event_label": vlabel}); } /* End of Kaltura player function code */

$(document).delegate("div[id^='play']", "click", function(){ //console.log($(this).attr("id")); //console.log($(this).attr("video-source")); //console.log($(this).attr("video-code")); var isyoutube = $(this).attr("video-source"); var vurl = $(this).attr("video-path"); var vid = $(this).attr("id"); $(this).hide(); var pvid = $(this).attr("newsid"); var vx = $(this).attr("id").replace('play-',''); var vC = $(this).attr("video-code"); var playDiv = "video-" + vid + "-" + pvid; if(isyoutube =='No'){ kalturaPlayerAPIReady(vC, playDiv,pvid); }else{ onYouTubePlay(vid, vC, playDiv,vx, pvid); } }); $(document).delegate("div[id^='ptop']", "click", function(){ var vid = $(this).attr("id").replace('ptop',''); $(this).hide(); var pvid = $(this).attr("newsid"); var vurl = $(this).attr("video-path"); //console.log($(this).attr("id") + "--" + vid); //console.log($(this).parent().children().find('#play-'+vid).attr("video-source")); //console.log($(this).parent().children().find('#play-'+vid).attr("video-code")); var isyoutube = $(this).parent().children().find('#play-'+vid).attr("video-source"); var vC = $(this).parent().children().find('#play-'+vid).attr("video-code"); var playDiv = "mvideo-play-" + vid + "-" + pvid; if(isyoutube =='No'){ //console.log(jwplayer($(this).attr("id")).getState()); kalturaPlayerAPIReady(vC, playDiv,pvid);

}else{ onYouTubePlay($(this).attr("id"), vC, playDiv, vid, pvid); } });

var nxti = 3; var ci = 1; var nxti_1 = 6; var nxti_2 = 9; var nxti_3 = 12; if($.autopager==false){ var use_ajax = false; /*var disqus_shortname="zeehindi"; var disqus_identifier; //made of post id and guid var disqus_url; //post permalink

function loadDisqus(source, identifier, url, nid) {

if (window.DISQUS) { //alert("if"); jQuery('

').insertAfter(source); jQuery('#disqus_thread').insertAfter(source); //append the HTML after the link //if Disqus exists, call it's reset method with new parameters DISQUS.reset({ reload: true, config: function () { this.page.identifier = identifier; this.page.url = url; } }); }else{ jQuery('

').insertAfter(source); disqus_identifier = identifier; //set the identifier argument disqus_url = url; //set the permalink argument

//append the Disqus embed script to HTML var dsq = document.createElement('script'); dsq.type="text/javascript"; dsq.async = true; dsq.src="http://" + disqus_shortname + '.disqus.com/embed.js'; jQuery('head').append(dsq); } };*/ /*$('.disqusOn').live( "click", notify ); function notify() { identifier = $(this).attr('id'); dUrl = $(this).attr('disqus-url'); source = $(this).parent(); loadDisqus(jQuery(this), identifier, dUrl); }*/ function loadshare(curl){ history.replaceState('' ,'', curl); if(window.OBR){ window.OBR.extern.researchWidget(); } //console.log("loadshare Call->" + curl); //$('html head').find('title').text("main" + nxtTitle); if(_up == false){ var cu_url = curl; gtag('config', 'UA-2069755-1', {'page_path': cu_url });

if(window.COMSCORE){ window.COMSCORE.beacon({c1: "2", c2: "9254297"}); var e = Date.now(); $.ajax({ url: "/marathi/news/zscorecard.json?" + e, success: function(e) {} }) } //console.log('ga:'+r); /*(function () { var ga = document.createElement('script'); ga.type="text/javascript"; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://' : 'http://') + 'stats.g.doubleclick.net/dc.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })();*/ //console.log("loadshare Call"); } } if(use_ajax==false) { //console.log('getting'); var view_selector="div.center-section"; // + settings.view_name; + '.view-display-id-' + settings.display; var content_selector = view_selector; // + settings.content_selector; var items_selector = content_selector + ' > div.rep-block'; // + settings.items_selector; var pager_selector="div.next-story-block > div.view-zn-article-mc-all-2017 > div.view-content > div.clearfix"; // + settings.pager_selector; var next_selector="div.next-story-block > div.view-zn-article-mc-all-2017 > div.view-content > div.clearfix > a:last"; // + settings.next_selector; var auto_selector="div.tag-block"; var img_location = view_selector + ' > div.rep-block:last'; var img_path="

Loading

"; //settings.img_path; //var img = '

' + img_path + '

'; var img = img_path; //$(pager_selector).hide(); //alert($(next_selector).attr('href')); var x = 0; var url=""; var prevLoc = window.location.pathname; var circle = ""; var myTimer = ""; var interval = 30; var angle = 0; var Inverval = ""; var angle_increment = 6; var handle = $.autopager({ appendTo: content_selector, content: items_selector, runscroll: maindiv, link: next_selector, autoLoad: false, page: 0, start: function(){ $(img_location).after(img); circle = $('.center-section').find('#green-halo'); myTimer = $('.center-section').find('#myTimer'); angle = 0; Inverval = setInterval(function (){ $(circle).attr("stroke-dasharray", angle + ", 20000"); //myTimer.innerHTML = parseInt(angle/360*100) + '%'; if (angle >= 360) { angle = 1; } angle += angle_increment; }.bind(this),interval); }, load: function(){ $('div.loading-block').remove(); clearInterval(Inverval); //$('.repeat-block > .row > div.main-rhs2360782').find('div.rhs2360782:first').clone().appendTo('.repeat-block >.row > div.main-rhs' + x); $('div.rep-block > div.main-rhs2360782 > div:first').clone().appendTo('div.rep-block > div.main-rhs' + x); $('.center-section >.row:last').before('

Next Story

'); //$(".main-rhs" + x).theiaStickySidebar(); var fb_script=document.createElement('script'); fb_script.text= "(function(d, s, id) {var js, fjs = d.getElementsByTagName(s)[0];if (d.getElementById(id)) return;js = d.createElement(s); js.id = id;js.src="https://connect.facebook.net/en_GB/sdk.js#xfbml=1&version=v2.9";fjs.parentNode.insertBefore(js, fjs);}(document, 'script', 'facebook-jssdk'));"; var fmain = $(".sr"+ x); //alert(x+ "-" + url); var fdiv = '

'; //$(fb_script).appendTo(fmain); $(fdiv).appendTo(fmain); FB.XFBML.parse(); var $dfpAd = $('.center-section').children().find("#ad-"+ x); xp = "#star"+x;

//var $dfpAdrhs = $('.main-rhs' + x).children().find('.adATF').empty().attr("id", "ad-300-" + x); //$('.content-area > .main-article > .row > .main-rhs'+x).find('#ad-300-' + x); //var $dfpAdrhs2 = $('.main-rhs' + x).children().find('.adBTF').empty().attr("id", "ad-300-2-" + x);//$('.content-area > .main-article > .row > .main-rhs'+x).find('#ad-300-2-' + x); //var $dfpMiddleAd = $('.content-area > .main-article > .row').find('#ar'+x).find('#ad-middle-' + x).empty(); //fillElementWithAd($dfpAdrhs, '/11440465/Zeenews_English_Web/Zeenews_English_AS_ATF_300x250', [[300, 250], [300, 600]], {}); //fillElementWithAd($dfpAdrhs2, '/11440465/Zeenews_English_Web/Zeenews_English_AS_BTF_1_300x250', [300, 250], {}); //fillElementWithAd($dfpMiddleAd, '/11440465/Zeenews_Hindi_Article_Middle_300x250_BTF', [300, 250], {}); var instagram_script=document.createElement('script'); instagram_script.defer="defer"; instagram_script.async="async"; instagram_script.src="https://platform.instagram.com/en_US/embeds.js";

/*var outbrain_script=document.createElement('script'); outbrain_script.type="text/javascript"; outbrain_script.async="async"; outbrain_script.src="https://widgets.outbrain.com/outbrain.js"; var Omain = $("#outbrain-"+ x); //alert(Omain + "--" + $(Omain).length);

$(Omain).after(outbrain_script); var rhs = $('.main-article > .row > div.article-right-part > div.rhs2360782:first').clone(); $(rhs).find('.ad-one').attr("id", "ad-300-" + x).empty(); $(rhs).find('.ad-two').attr("id", "ad-300-2-" + x).empty(); //$('.main-article > .row > div.article-right-part > div.rhs2360782:first').clone().appendTo('.main-article > .row > div.main-rhs' + x); $(rhs).appendTo('.main-article > .row > div.main-rhs' + x); */

setTimeout(function(){

var twit = $("div.field-name-body").find('blockquote[class^="twitter"]').length; var insta = $("div.field-name-body").find('blockquote[class^="instagram"]').length; if(twit==0){twit = ($("div.field-name-body").find('twitterwidget[class^="twitter"]').length);} if(twit>0){ if (typeof (twttr) != 'undefined') { twttr.widgets.load();

} else { $.getScript('https://platform.twitter.com/widgets.js'); } //$(twit).addClass('tfmargin'); } if(insta>0){ $('.content > .left-block:last').after(instagram_script); //$(insta).addClass('tfmargin'); window.instgrm.Embeds.process(); } }, 1500); } }); /*$("#loadmore").click(function(){ x=$(next_selector).attr('id'); var url = $(next_selector).attr('href'); disqus_identifier="ZNH" + x; disqus_url = url; handle.autopager('load'); history.pushState('' ,'', url); setTimeout(function(){ //twttr.widgets.load(); //loadDisqus(jQuery(this), disqus_identifier, disqus_url); }, 6000); });*/

/*$("button[id^='mf']").live("click", disqusToggle); function disqusToggle() { console.log("Main id: " + $(this).attr('id')); }*/ $(document).delegate("button[id^='mf']", "click", function(){ fbcontainer=""; fbid = '#' + $(this).attr('id'); var sr = fbid.replace("#mf", ".sr");

//console.log("Main id: " + $(this).attr('id') + "Goodbye!jQuery 1.4.3+" + sr); $(fbid).parent().children(sr).toggle(); fbcontainer = $(fbid).parent().children(sr).children(".fb-comments").attr("id"); //console.log(fbcontainer); //var commentsContainer = document.getElementById(fbcontainer); //commentsContainer.innerHTML = '';

}); /************Player Code ***********/ var title, imageUrl, description, author, shortName, identifier, timestamp, summary, newsID, nextnews; var previousScroll = 0; //console.log("prevLoc" + prevLoc); $(window).scroll(function(){ var last = $(auto_selector).filter(':last'); var lastHeight = last.offset().top ; //st = $(layout).scrollTop(); //console.log("st:" + st); var currentScroll = $(this).scrollTop(); if (currentScroll > previousScroll){ _up = false; } else { _up = true; } previousScroll = currentScroll; //console.log("_up" + _up);

var cutoff = $(window).scrollTop() + 64; //console.log(cutoff + "**"); $('div[id^="row"]').each(function(){ //console.log("article" + $(this).children().find('.left-block').attr("id") + $(this).children().find('.left-block').attr('data-url')); if($(this).offset().top + $(this).height() > cutoff){ //console.log("$$" + $(this).children().find('.left-block').attr('data-url')); if(prevLoc != $(this).children().find('.left-block').attr('data-url')){ prevLoc = $(this).children().find('.left-block').attr('data-url'); $('html head').find('title').text($(this).children().find('.left-block').attr('data-title')); $('meta[name=description]').attr("content",$(this).children().find('.left-block').attr('data-summary')); $('meta[name=keywords]').attr("content",$(this).children().find('.left-block').attr('data-keyword')); $('meta[name=news_keywords]').attr("content",$(this).children().find('.left-block').attr('data-keyword'));

pSUPERFLY.virtualPage(prevLoc,$(this).children().find('.left-block').attr('data-title')); //console.log("Summary: " + $(this).children().find('.left-block').attr('data-summary')); //console.log("Keyword: " + $(this).children().find('.left-block').attr('data-keyword')); //history.pushState('' ,'', prevLoc); loadshare(prevLoc); } return false; // stops the iteration after the first one on screen } }); if(lastHeight + last.height() < $(document).scrollTop() + $(window).height()){ //console.log("**get"); url = $(next_selector).attr('href'); x=$(next_selector).attr('id'); //console.log("x:" + x); //handle.autopager('load'); /*setTimeout(function(){ //twttr.widgets.load(); //loadDisqus(jQuery(this), disqus_identifier, disqus_url); }, 6000);*/ } //lastoff = last.offset(); //console.log("**" + lastoff + "**"); }); //$( ".content-area" ).click(function(event) { // console.log(event.target.nodeName); //}); /*$( ".comment-button" ).live("click", disqusToggle); function disqusToggle() { var id = $(this).attr("id"); $("#disqus_thread1" + id).toggle(); };*/ //$(".main-rhs2360782").theiaStickySidebar(); var prev_content_height = $(content_selector).height(); //$(function() { var layout = $(content_selector); var st = 0; ///}); } } }); /*} };*/ })(jQuery);
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